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While clozapine can provide great benefitsit can rarely cause seriouspossibly fatal side effectsFor this reasonclozapine is used when other treatments have not worked or you cannot take them.
During pregnancythis medication should be used only when clearly neededBabies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakinessdrowsinessfeeding/breathing difficultiesor constant cryingIf you notice any of these symptoms in your newborn especially during their first monthtell the doctor right away.
Many drugs can interact with clozapineNot all possible interactions are listed hereTell your doctor about all your current medicines and any you start or stop usingespecially:
Clozapine can also cause seizuresespecially in higher dosesLet your doctor or pharmacist know if you have ever had seizuresWhile taking this medicationavoid driving or other activities during which a sudden loss of consciousness could be dangerouse.goperating heavy machineryswimming
Patients with hepatic impairment should receive Clozaril with caution along with regular monitoring of liver function testssee section 4.4
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on the other hand, if a patient is stabilised on clozaril and not treatment refractory, then cautious switching to a generic formulation may be reasonable.